Téléchargez le livre : Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy

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Éditeur :

Springer


Collection :

Current Topics in Microbiology and Immunology

Paru le : 2011-04-11

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Description
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
Pages
306 pages
Collection
Current Topics in Microbiology and Immunology
Parution
2011-04-11
Marque
Springer
EAN papier
9783642141355
EAN EPUB
9783642141362
Informations sur l'ebook
Nombre pages copiables
3
Nombre pages imprimables
30
Taille du fichier
1772 Ko
Prix
210,99 €

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