Téléchargez le livre : Anoikis

Anoikis

How the Extracellular Matrix Regulates Life-or-Death Decisions

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Springer


Paru le : 2021-07-27



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Description

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions.  Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant.  In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis.  While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized.  The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment;  c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment;  e. regulation by EMT.
Pages
202 pages
Collection
n.c
Parution
2021-07-27
Marque
Springer
EAN papier
9783030738549
EAN PDF
9783030738563
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
20
Taille du fichier
5079 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
126,59 €
EAN EPUB
9783030738563
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
20
Taille du fichier
10732 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
126,59 €
Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.

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