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Description

Telomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres.
The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here.
Two chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.
Pages
400 pages
Collection
n.c
Parution
2024-06-12
Marque
Wiley-ISTE
EAN papier
9781789450972
EAN PDF
9781394300785
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
400
Taille du fichier
16026 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
148,86 €
EAN EPUB
9781394300792
Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
400
Taille du fichier
4485 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
148,86 €

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