Téléchargez le livre : Decoding Aging and Neurodegeneration

Decoding Aging and Neurodegeneration

The Role of Nucleic Acid Epigenetics

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Springer


Paru le : 2025-06-12



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Description

This book focuses on the close relationship between aging and neurodegeneration. By highlighting the reversible nature of epigenetic changes, it provides a comprehensive overview of how these modifications can regulate gene expression without altering the DNA sequence, offering promising solutions for clinical intervention.
Aging induces a gradual decline in cerebral function, leading to cognitive impairment, memory loss, motor dysfunction, and eventually functional decline and death. It is accompanied by the decline of organismal functions induced by whole genome alterations leading to neurodegeneration. Epigenetic modifications, including chromatin modifications, DNA methylation, and changes in regulatory RNAs, have a major impact on neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
The chapters in this book address critical issues such as the contribution of epigenetic mechanisms to aging, the interaction between genetic and environmental factors in neurodegeneration, and the potential for epigenetic therapies to delay aging and mitigate disease progression.
This volume, part of the RNA Technologies book series, is an invaluable resource for researchers and advanced students in genetics and neuroscience. It provides a deep understanding of the molecular basis of neurodegenerative diseases and offers innovative strategies to address the challenges of aging and neurodegeneration. 
Pages
403 pages
Collection
n.c
Parution
2025-06-12
Marque
Springer
EAN papier
9783031910715
EAN PDF
9783031910722
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
40
Taille du fichier
25364 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
231,04 €
EAN EPUB
9783031910722
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
40
Taille du fichier
23071 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
231,04 €
Jan Barciszewski is Professor at Adam Mickiewicz University (AMU) in Poznan, Poland, and at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznan, Poland, where he has worked since 1974. He studied organic chemistry at the AMU. During his Ph.D. studies, he worked on the structure and function of modified bases and nucleoside sequences of plant phenylalanine-specific transfer ribonucleic acid (tRNA), including cytokinins. He was subsequently granted Doctor of Science degree for his work on the properties of plant tRNAs and aminoacyl-tRNA synthetases. In the 1990s, he began working on the diagnosis and therapy of brain tumors. He developed a new method for the transformation of plant mitochondria based on catalytic RNAs and is currently involved in studies on a new type of catalytic RNAs (enantiomeric ribozymes) for efficient RNA target cleavage in vivo, as well as the search for new anti-aging agents. He is also interested in circular RNAs biogenesis.

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