Chemokines and Viral Infection

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Éditeur :

Springer


Collection :

Current Topics in Microbiology and Immunology

Paru le : 2007-05-30

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Description
Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.
Pages
160 pages
Collection
Current Topics in Microbiology and Immunology
Parution
2007-05-30
Marque
Springer
EAN papier
9783540292074
EAN PDF
9783540333975

Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
16
Taille du fichier
2089 Ko
Prix
147,69 €