Téléchargez le livre : B Cell Receptor Signaling

B Cell Receptor Signaling

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Éditeur :

Springer


Collection :

Current Topics in Microbiology and Immunology

Paru le : 2015-12-26

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Description

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.
Pages
231 pages
Collection
Current Topics in Microbiology and Immunology
Parution
2015-12-26
Marque
Springer
EAN papier
9783319261317
EAN PDF
9783319261331
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
23
Taille du fichier
5212 Ko
Prix
147,69 €
EAN EPUB
9783319261331
Informations sur l'ebook
Nombre pages copiables
2
Nombre pages imprimables
23
Taille du fichier
1362 Ko
Prix
147,69 €

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