Téléchargez le livre : Modified Nucleic Acids in Biology and Medicine
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Description

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties.
The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.
Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levelsof the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides.
This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
 
Pages
453 pages
Collection
RNA Technologies
Parution
2016-07-29
Marque
Springer
EAN papier
9783319341736
EAN PDF
9783319341750
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
45
Taille du fichier
10516 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
179,34 €
EAN EPUB
9783319341750
Informations sur l'ebook
Nombre pages copiables
4
Nombre pages imprimables
45
Taille du fichier
3645 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
179,34 €

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