Téléchargez le livre : Impact of Survivin Acetylation on its Biological Function

Impact of Survivin Acetylation on its Biological Function



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Éditeur :

Springer Spektrum


Collection :

BestMasters

Paru le : 2017-06-06



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Description

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.
Pages
104 pages
Collection
BestMasters
Parution
2017-06-06
Marque
Springer Spektrum
EAN papier
9783658186227
EAN PDF
9783658186234
Informations sur l'ebook
Nombre pages copiables
1
Nombre pages imprimables
10
Taille du fichier
6257 Ko
Ce livre est accessible aux handicaps Voir les informations sur l'accessibilité
Prix
52,74 €

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