Modelling Proteasome Dynamics in a Bayesian Framework



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Éditeur :

Springer Spektrum


Collection :

BestMasters

Paru le : 2017-11-30



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Description

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
Pages
96 pages
Collection
BestMasters
Parution
2017-11-30
Marque
Springer Spektrum
EAN papier
9783658201661
EAN PDF
9783658201678

Informations sur l'ebook
Nombre pages copiables
0
Nombre pages imprimables
9
Taille du fichier
3297 Ko
Prix
52,74 €