Daniel C. Sigg, MD, PhD is Adjunct Assistant Professor of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA Paul A. Iaizzo, PhD PhD is Professor of Surgery, Integrative Biology and Physiology and The Carlson School of Management, he is also Director of Education of the Lillehei Heart Institute and Associate Director for the Institute for Engineering in Medicine, he also holds the Medtronic Professorship for Visible Heart Research , University of Minnesota, Minneapolis, Minnesota, USA Yong-Fu Xiao, MD, PhD is Principal Scientist at Medtronic, Inc., New Therapies & Diagnostics Management, Cardiac Rhythm Disease Management, Mounds View, MN, USA Bin He, PhD is Distinguished McKnight University Professor and Professor of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA