Télécharger le livre :  The Neuropharmacology of Alcohol
This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some...

Editeur : Springer
Parution : 2019-03-27
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  New Psychoactive Substances
This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly...

Editeur : Springer
Parution : 2019-02-20
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Télécharger le livre :  Mechanisms of Drug Resistance in Cancer Therapy
A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient...

Editeur : Springer
Parution : 2019-01-10
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Télécharger le livre :  Delta Opioid Receptor Pharmacology and Therapeutic Applications
This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system...

Editeur : Springer
Parution : 2018-09-27
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Voltage-gated Sodium Channels: Structure, Function and Channelopathies
This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study...

Editeur : Springer
Parution : 2018-06-04
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Télécharger le livre :  Targeting Trafficking in Drug Development
Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular...

Editeur : Springer
Parution : 2018-04-18
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Sigma Proteins: Evolution of the Concept of Sigma Receptors
Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical...

Editeur : Springer
Parution : 2017-10-05
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Pharmacology of Mitochondria
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by...

Editeur : Springer
Parution : 2017-08-11
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Heart Failure
This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and...

Editeur : Springer
Parution : 2017-06-09
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Pharmacologic Therapy of Ocular Disease
There have been major advancements in the pharmacologic treatment of eye diseases over the past decade. With newly discovered disease targets and novel approaches to deliver therapeutic compounds to the eye, patients are seeing improved outcomes. Not only are there...

Editeur : Springer
Parution : 2017-06-05
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Histamine and Histamine Receptors in Health and Disease
This ?book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field...

Editeur : Springer
Parution : 2017-05-22
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Non-canonical Cyclic Nucleotides
The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic...

Editeur : Springer
Parution : 2017-04-28
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Télécharger le livre :  Gastrointestinal Pharmacology
This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing...

Editeur : Springer
Parution : 2017-04-19
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Free Fatty Acid Receptors
This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors....

Editeur : Springer
Parution : 2017-02-08
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Pharmacology and Therapeutics of Asthma and COPD
The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the...

Editeur : Springer
Parution : 2017-02-06
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  The Actin Cytoskeleton
Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of...

Editeur : Springer
Parution : 2017-01-03
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Adhesion G Protein-coupled Receptors
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion...

Editeur : Springer
Parution : 2016-11-09
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  New Approaches to Drug Discovery
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The...

Editeur : Springer
Parution : 2016-03-30
Collection : Handbook of Experimental Pharmacology ePub

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Télécharger le livre :  Metabolic Control
The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional...

Editeur : Springer
Parution : 2016-03-17
Collection : Handbook of Experimental Pharmacology ePub

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Télécharger le livre :  Endocannabinoids
There is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced “autoprotection”, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose...

Editeur : Springer
Parution : 2015-09-25
Collection : Handbook of Experimental Pharmacology PDF, ePub

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