Télécharger le livre :  Voltage-gated Sodium Channels: Structure, Function and Channelopathies
This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study...

Editeur : Springer
Parution : 2018-06-04
Collection : Handbook of Experimental Pharmacology PDF

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Télécharger le livre :  Targeting Trafficking in Drug Development
Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular...

Editeur : Springer
Parution : 2018-04-18
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Sigma Proteins: Evolution of the Concept of Sigma Receptors
Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical...

Editeur : Springer
Parution : 2017-10-05
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Pharmacology of Mitochondria
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by...

Editeur : Springer
Parution : 2017-08-11
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Heart Failure
This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and...

Editeur : Springer
Parution : 2017-06-09
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Gastrointestinal Pharmacology
This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing...

Editeur : Springer
Parution : 2017-04-19
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Free Fatty Acid Receptors
This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors....

Editeur : Springer
Parution : 2017-02-08
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Pharmacology and Therapeutics of Asthma and COPD
The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the...

Editeur : Springer
Parution : 2017-02-06
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  The Actin Cytoskeleton
Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of...

Editeur : Springer
Parution : 2017-01-03
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Adhesion G Protein-coupled Receptors
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion...

Editeur : Springer
Parution : 2016-11-09
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  New Approaches to Drug Discovery
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The...

Editeur : Springer
Parution : 2016-03-30
Collection : Handbook of Experimental Pharmacology ePub

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Télécharger le livre :  Metabolic Control
The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional...

Editeur : Springer
Parution : 2016-03-17
Collection : Handbook of Experimental Pharmacology ePub

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Télécharger le livre :  Endocannabinoids
There is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced “autoprotection”, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose...

Editeur : Springer
Parution : 2015-09-25
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide
This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states....

Editeur : Springer
Parution : 2015-07-10
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Principles of Safety Pharmacology
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive...

Editeur : Springer
Parution : 2015-06-19
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Cognitive Enhancement
This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging...

Editeur : Springer
Parution : 2015-05-14
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Pharmacology of Itch
Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and...

Editeur : Springer
Parution : 2015-04-10
Collection : Handbook of Experimental Pharmacology ePub

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Télécharger le livre :  Pain Control
This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the...

Editeur : Springer
Parution : 2015-04-06
Collection : Handbook of Experimental Pharmacology ePub

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Télécharger le livre :  High Density Lipoproteins
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure,...

Editeur : Springer
Parution : 2014-12-18
Collection : Handbook of Experimental Pharmacology PDF, ePub

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Télécharger le livre :  Placebo
Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be...

Editeur : Springer
Parution : 2014-10-10
Collection : Handbook of Experimental Pharmacology ePub

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